Endocrine Abstracts

Context: Vitamin D is a fat-soluble vitamin which requires the hydroxylation into 1,25-dihydroxyvitamin D (1,25-(OH)2D3) to be fully active. Vitamin D deficiency is a worldwide health problem associated to a wide range of acute and chronic diseases. On other hand, vitamin D supplementation has been proposed to reduced the risk of metabolic dysfunctions including obesity, type 2 diabetes and cardiovascular disease. Vitamin D interacts with the epigenetic m...

Context: Metabolic diseases affect millions of people in both developed and transition countries. In addition to genetic inheritance of risk alleles, emerging evidence has shown that these diseases are also linked to lifestyle and inherited epigenetic pattern interactions. The strong link between epigenetics and metabolism may offer attractive clinical applications to counteract and manage the escalating prevalence of metabolic diseases, such as obesity, type 2 diabetes mellit...

Context: Obesity is a global epidemic and an independent risk factor for several metabolic disorders. Emerging evidence suggests a role for epigenetic factors, such as microRNAs (miRNAs), in the development of obesity. MiRNAs are small non-coding RNAs that regulate gene expression. Moreover, circulating miRNAs are potential noninvasive biomarkers because they are stable in body fluids and can be detected using validated techniques, such as quantitative PCR. However, the identi...

67 y/o old female, with long history of hyperthyroidism, without treatment and hypertension. Two months prior to admission, she received amiodarone 200 mg daily due to cardiac arrhythmia. One week prior to admission, she developed symptoms of Congestive Heart Failure and weight loss. Family history: hyperthyroidism in two sisters. Physical examination: acutely ill, thin female, in moderate respiratory distress. Alert, oriented x 3.BP: 155/119 mmHg HR: 150.Prominent findings: m...

Objective: Evaluate the utility of analytical determination of parathyroid hormone assay in fine-needle aspirate as a diagnostic test for parathyroid adenoma in patients with primary hyperparathyroidism.Material and Methods: retrospective observational study of 58 patients diagnosed with primary hyperparathyroidism in our hospital who underwent ultrasound-guided FNA of lesions compatible with parathyroid adenoma with determination of PTH in fine-needle a...

Background and aims: Use of potassium iodide (PI) supplements during gestation in mild to moderate iodine deficiency areas remains a controversial issue.Objective: Comparing the pharmacological effect of iodized salt versus iodide potassium supplements on the maternal thyroid function and neurodevelopment (Bayley Scales) of the progeny.Methods: One hundred and thirty one pregnant women were included from the first trimester (below ...

51 y/o female with past medical history of migraine headache, brought to UR because of hypoactivity, generalized weakness, confusion, lack of balance and dysarthria since one day of evolution. No medications. No Habits. Past history: negative for hypertension, cardiac disease or dyslipidemia. Physical examination: normal vital signs and weight. Alert, awake, and oriented only in person. Palpable nontender left thyroid lobe. Bilateral hyperreflexia.Labs: ...

Central treatment with ghrelin increases body weight and fat accumulation. Here we explore the pharmacological effect of a combined central (ICV) infusion of ghrelin (0.3 nmol/day) and a recently developed ghrelin receptor (GHS-R1A) antagonist (JMV2959, 100 nmol/day) on food intake and body composition. The effect of ghrelin infusion for 14 days to increase body weight (20.7±0.9% vs 34.3±3.1%, saline vs ghrelin, P<0.001) was blocked by co-infusion with JMV...

A 49 years old male patient with 12 years history of poorly controlled type 2 diabetes mellitus on insulin therapy, complicated with neuropathy, nephropathy, retinopathy, peripheral arterial disease (right toe amputation), hypertension and dyslipidemia. He presented with upper extremities proximal muscle and upper back moderate pain that progressed to excruciating pain with restriction of motion, weakness, and stiffness of 3 days of evolution. He denied trauma, abnormal exerci...

Introduction: Identification of early responders is widely used in pharmacotherapy for weight loss to minimize unnecessary exposure to risks and unnecessary expenses. Gelesis Loss Of Weight (GLOW; NCT02307279), a multicenter, double-blind, placebo-controlled pivotal study, demonstrated that Gelesis100 offers a compelling new potential approach in the management of overweight and obesity.Objective: A post-hoc area under the curve (AUC) for the receiver op...